Blisters are typically caused by friction, pressure, or rubbing against the skin, which can cause the outer layer of the skin to separate from the underlying tissue and fill with fluid. The fluid inside a blister is called serum, which is a clear, watery fluid that is similar in composition to blood plasma.
In general, it is better to leave a blister intact rather than popping it, as popping a blister can increase the risk of infection and delay healing. The fluid inside a blister helps to protect the underlying skin from further damage and allows the skin to heal naturally.

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